Yuchao Jiang

Assistant Professor, Department of Biostatistics
Assistant Professor, Department of Genetics
Member, Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill

Education

PhD, Genomics and Computational Biology, University of Pennsylvania, 2017

MA, Statistics, University of Pennsylvania 2014

BA, magna cum laude, Cornell University 2012


Publications

Jiang Y, Oldridge DA, Diskin SJ, Zhang NR. CODEX: a normalization and copy number variation detection method for whole exome sequencing. Nucleic Acids Research, 43 (6), e39-e39, 2015. (link)

Jiang Y, Qiu Y, Minn AJ, Zhang NR. Assessing tumor heterogeneity and tracking longitudinal and spatial clonal evolution by next-generation sequencing. Proceedings of the National Academy of Sciences, 113 (37), E5528-E5537, 2016. (link, news)

Jiang Y, Zhang NR, Li M. SCALE: modeling allele-specific gene expression by single-cell RNA sequencing. Genome Biology, 18 (1), 74, 2017. (link)

Chen H, Jiang Y, Maxwell KN, Nathanson KL, Zhang NR. Allele-specific copy number estimation by whole exome sequencing. Annals of Applied Statistics, 11 (2), 1169-1192, 2017. (link)

Maxwell KN, Wubbenhorst B, Wenz BM, De Sloover D, Pluta J, Emery L, Barrett A, Kraya AA, Anastopoulos IN, Yu S, Jiang Y, Chen H, Zhang NR, Hackman N, D’Andrea K, Daber R, Morrissette JJD, Mitra N, Feldman M, Domchek SM, Nathanson KL. BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers. Nature Communications, 8 (1), 319, 2017. (link)

Garman B, Anastopoulos IN, Krepler C, Brafford P, Sproesser K, Jiang Y, Wubbenhorst B, Amaravadi R, Bennett J, Beqiri M, Elder D, Flaherty KT, Frederick DT, Gangadhar TC, Guarino M, Hoon D, Karakousis G, Liu Q, Mitra N, Petrelli NJ, Schuchter L, Shannan B, Shields CL, Wargo J, Wenz B, Wilson MA, Xiao M, Xu W, Xu X, Yin X, Zhang NR, Davies MA, Herlyn M, Nathanson KL. Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines. Cell Reports, 21 (7), 1936-1952, 2017. (link)


Teaching

Instructor: STAT 101, Introductory Business Statistics, Wharton School, University of Pennsylvania, 2016 Summer (syllabus)


Software

CODEX: COpy number Detection by EXome sequencing (BioC, vignettes)

Canopy: Copy number and single nucleotide mutation analysis of tumor phylogeny (GitHub, CRAN, vignettes)

SCALE: Single Cell ALlelic Expression (GitHub, vignettes)

CODEX2: Full-Spectrum Copy Number Variation Detection by High-Throughput DNA Sequencing (GitHub)


Contact

Email: yuchaoj at email dot unc dot edu

Address:

4115D McGavran-Greenberg Hall, CB #7420, Chapel Hill, NC 27599-7420 (Biostatistics)

5112 Genetic Medicine Building, CB #7264, Chapel Hill, NC 27599-7264 (Genetics)

Phone: (919)843-3656

Fax: (919)966-3804